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<h4><br>To explore the effect of IL-17A concentration on the function of SynNotch with the presence of IL-6, various concentrations of IL-17A were given and the expression of USP7 and FOXP3 was tested. With a higher concentration of IL-17A, a higher expression of USP7 and FOXP3 was detected, indicating that the concentration of IL-17A played an important role in the expression level of SynNotch.</h4> | <h4><br>To explore the effect of IL-17A concentration on the function of SynNotch with the presence of IL-6, various concentrations of IL-17A were given and the expression of USP7 and FOXP3 was tested. With a higher concentration of IL-17A, a higher expression of USP7 and FOXP3 was detected, indicating that the concentration of IL-17A played an important role in the expression level of SynNotch.</h4> | ||
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− | <center><img src="https://static.igem.org/mediawiki/2017/ | + | <center><img src="https://static.igem.org/mediawiki/2017/3/3a/T--CPU_CHINA--results_fig2.png" width = "800"></center> |
<h4 align=middle>Figure9. The SynNotch system stabilizing FOXP3 in Treg under inflammatory conditions</h4> | <h4 align=middle>Figure9. The SynNotch system stabilizing FOXP3 in Treg under inflammatory conditions</h4> | ||
</div> | </div> |
Revision as of 18:12, 1 November 2017