Team:Groningen
Summary
In the Netherlands, export of dairy products, such as cheese, buttermilk, and yogurt generate a combined yearly income of billions of euros with the Netherlands being responsible for 5% of the world’s dairy product trade. The bacteria used for the fabrication of these commodities are severely susceptible to viral infections, which can disrupt production capabilities of the product. The iGEM (international Genetically Engineered Machine competition) Groningen team is determined to improve the current quality control standard practices by developing an improved system for the detection of phage infections. By implementation of our system, the Groningen iGEM team hopes to contribute to the on-going efforts to safeguard the production and ensure better quality product and subsequent export of our world famous dairy products. The mission of the Groningen iGEM 2017 project is to design a system that can be used to survey and detect multiple pre-programmed nucleotide sequences and result in a convenient readout. To do so, a CRISPR-based detection system will be developed that can be utilized to detect bacteriophages, bacterial viruses. This system will rely on the DNA sequence detection capabilities of a modified version of the “adaptive immune system” of bacteria, CRISPR-Cas. Various readout modules will be implemented to allow for proactive, quick, cheap and reliable screening of high-risk bacteriophage infections in the industrial pipeline.
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