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− | <h4><br>In order to theoretically demonstrate that regulatory T cells are dysfunctional or transdifferentiated in the cell microenvironment of rheumatoid arthritis patients imbued with a large number of inflammatory factors, and to describe the necessity of intervening the corresponding regulatory pathway of Treg cells in the clinical treatment of rheumatoid arthritis, we established the mathematical model of T cell differentiation and transdifferentiation (see more from<a href="https://2017.igem.org/Team:CPU_CHINA/Model"> | + | <h4><br>In order to theoretically demonstrate that regulatory T cells are dysfunctional or transdifferentiated in the cell microenvironment of rheumatoid arthritis patients imbued with a large number of inflammatory factors, and to describe the necessity of intervening the corresponding regulatory pathway of Treg cells in the clinical treatment of rheumatoid arthritis, we established the mathematical model of T cell differentiation and transdifferentiation (see more from<a href="https://2017.igem.org/Team:CPU_CHINA/Model">Modeling section</a>). |
</h4> | </h4> | ||
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</div> | </div> | ||
<h3 class="ar-title">Summary of Mathematical Models</h3> | <h3 class="ar-title">Summary of Mathematical Models</h3> | ||
− | <h4><br>In order to further evaluate the clinical value of our system and provide a theoretical reference for the next in vivo and preclinical experiments, we also establish a systematic mathematical model for the local and overall immune environment of rheumatoid arthritis (See the | + | <h4><br>In order to further evaluate the clinical value of our system and provide a theoretical reference for the next in vivo and preclinical experiments, we also establish a systematic mathematical model for the local and overall immune environment of rheumatoid arthritis (See the Modeling section for details). Thus, we have a theoretical explanation of the relationships among the cytokines, different cell subpopulations and rheumatoid arthritis, which lays a solid foundation for further improvement of our research ideas regarding the subsequent in vivo and preclinical experiments </h4> |
<div> | <div> | ||
<center><img src="https://static.igem.org/mediawiki/2017/0/0c/T--CPU_CHINA--description_11_1_8.png" width = "700"></center> | <center><img src="https://static.igem.org/mediawiki/2017/0/0c/T--CPU_CHINA--description_11_1_8.png" width = "700"></center> |
Latest revision as of 15:28, 1 November 2017