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            <h3 class="team_name">Dr Russell Brown</h3>
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Revision as of 17:16, 28 August 2017

PhagED: a molecular toolkit to re-sensitise ESKAPE pathogens

Antibiotic revolution: a molecular toolkit to re-sensitise
Methycillin resistant S.aureus (MRSA) Vancomycin resistant S.aureus (VRSA) Klebsiella pneumoniae Pseudomonas aeruginosa Enterococcus faecalis/faecium Acinetobacter baumanii

Modular molecular toolkit for re-sensitisation of antibiotic-resistant pathogens using CRISPR delivered by a two-phage system.

Read more

ABOUT PhagED

The world is currently facing a future where antibiotics no longer work and basic infections cannot be treated. Many of the most dangerous diseases which are not treatable arise from the hospital environment. This is because the bacteria have had lots of exposure to antibiotics, allowing them time to evolve genes which can help them survive in the presence of these drugs. We therefore want to tackle this problem of the 'super bugs' found in our hospitals, otherwise known as the ESKAPE pathogens.

We will do this by developing a spray which will contain modified phages. When that phage enters the cell, CRISPR-Cas system will cut up the genes which are giving the bacteria resistance to antibiotics. We then add another phage to ensure this system is maintainable.

By using this spray, we hope to re-sensitise these dangerous antibiotic resistant bacteria to the drugs again, allowing conventional antiobiotics to work. This would mean we would no longer need to develop costly new antibiotics, and avoid the coming doom of a world where a UTI is a death sentence. Neat eh?!

TAKE A CLOSER LOOK

Project

Get to know PhagED better.

Parts

Blocks of DNA that we've used.

Safety

Safety always comes first.

Human Practices

How does PhagED fit into the context of our lives?

Meet The Team

Filippo Abbondanza

MSc Synthetic Biology & Biotechnology

Developing the lysoenic lambda phage carrying the FnCpf1 CRISPR system.

Erin Corbett

MSc Synthetic Biology & Biotechnology

Engineering E. coli to create our mock pathogen testing platform, and engineering the lytic T7 phage.

Yunqi He

MSc Biochemistry

Developing the lysogenic P1 phage carrying spCas9 CRISPR system.

Ti He

MSc Biotechnology

Developing the lysogenic lambda phage carring saCas9 CRISPR system.

Lydia Mapstone

MSc Synthetic Biology & Biotechnology

Engineering E. coli to create our mock pathogen testing platform and engineering the lytic T4 phage using BRED.

Yuri Matsueda

MSc Biotechnology

Engineering P1 lysogenic phage with CRISPR-SaCas9 system to target resistance gene fragments.

Anton Puzorjov

MSc Bioinformatics

Building a model of bacteria-phage interactions in two-step re-sensitisation combining both lysogenic and lytic phages.

Yating Wang

MSc Drug Discovery & Translational Biology

Engineering P1 lysogenic phage with CRISPR-Cpf1 system to target resistance gene fragments.


Owen Yeung

MSc Synthetic Biology & Biotechnology

Developing the lysoenic lambda phage carrying the SpCas9 CRISPR system.

Supervisors

Dr Elise Cachat

School of Biological Sciences

Academic supervisor.

Dr Heather Barker

School of Biological Sciences

Supervising lab work.

Holly Robertson-Dick

Industrial Liaison

Supervising iGEM administrative work.

Dr John White

School of Chemistry

Supervising phage work.

Dr Filippo Menolascina

School of Bioengineering

Supervising bacteria-phage modelling.

Dr Russell Brown

School of Biological Sciences

Supervising P1 phage construction.

Sponsors

We are very thankful to those who are helping us to make it happen.

DO YOU WANT TO HELP US TURN IT INTO REALITY?

We will be more than happy to accept any kind of support from you either in cash or as free/discounted services or consumables.

    • Bronze

      £ 500
      • Logo on website
      • Recognition on social media
      • Logo on t-shirts
      • Logo on media content
      • Logo on presentation
      • Logo on official poster
    • Silver

      £ 1,000
      • Logo on website
      • Recognition on social media
      • Logo on t-shirts
      • Logo on media content
      • Logo on presentation
      • Logo on official poster
    • Gold

      £ 2,000
      • Logo on website
      • Recognition on social media
      • Logo on t-shirts
      • Logo on media content
      • Logo on presentation
      • Logo on official poster
    • Platinum

      £ 2,500
      • Logo on website
      • Recognition on social media
      • Logo on t-shirts
      • Logo on media content
      • Logo on presentation
      • Logo on official poster

FEEL FREE TO GET IN TOUCH

Contact