Difference between revisions of "Team:Edinburgh OG/HP/Gold Integrated"

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<p>Through discussions with experts from both the healthcare and animal industries, we realised that a spray wasn&rsquo;t the best way to deploy our system.</p>
 
<p>Through discussions with experts from both the healthcare and animal industries, we realised that a spray wasn&rsquo;t the best way to deploy our system.</p>
 
<p>In hospital settings, powdered detergents and dissolvable cleaning agents are commonly used instead of sprays. Therefore, we decided to focus on PhagED as a powder rather than a spray. As our computational model demonstrated, the provision of nutrients to the system enhances the ability of the phages to remove resistant bacteria. Nutrient powder could therefore be mixed with the powdered phages to create the most efficient possible PhagED. By encapsulating the powdered phages in different coatings, their rate of dissolving can be controlled - allowing the system to be applied in a single stage while ensuring that the lysogenic phages are the first to contact the resistant bacteria.</p>
 
<p>In hospital settings, powdered detergents and dissolvable cleaning agents are commonly used instead of sprays. Therefore, we decided to focus on PhagED as a powder rather than a spray. As our computational model demonstrated, the provision of nutrients to the system enhances the ability of the phages to remove resistant bacteria. Nutrient powder could therefore be mixed with the powdered phages to create the most efficient possible PhagED. By encapsulating the powdered phages in different coatings, their rate of dissolving can be controlled - allowing the system to be applied in a single stage while ensuring that the lysogenic phages are the first to contact the resistant bacteria.</p>
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<div class="dif-fig"><img src="https://static.igem.org/mediawiki/2017/6/65/T--Edinburgh_OG--hpgold_fig2.png"></div>
 
 
<p>Powdered PhagED would also be applicable in farm environments, where it could be used for cleaning equipment etc., but also potentially as a food additive. For a product like this to be viable, it would have to be cost-effective and easily incorporated into current routines and treatments.</p>
 
<p>Powdered PhagED would also be applicable in farm environments, where it could be used for cleaning equipment etc., but also potentially as a food additive. For a product like this to be viable, it would have to be cost-effective and easily incorporated into current routines and treatments.</p>
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<div class="div-fig" style="width:200px;"><img src="https://static.igem.org/mediawiki/2017/6/65/T--Edinburgh_OG--hpgold_fig2.png"></div>
 
<p>To see the key points that we learnt from each expert and how they affected our plans for PhagED, click on the photographs below.</p>
 
<p>To see the key points that we learnt from each expert and how they affected our plans for PhagED, click on the photographs below.</p>
 
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Revision as of 22:38, 31 October 2017

PhagED: a molecular toolkit to re-sensitise ESKAPE pathogens

Gold Medal and Integrated Human Practices

  • Expert Perspectives

    • We interviewed a number of people to learn more about how antibiotic resistance impacts them and how they think our project could fit into their work.

    We learnt a lot from the experts we interviewed, especially with regards to the real world uses of PhagED. When we started the project, our plan was for PhagED to be used in spray form to clean hospital surfaces - one spray for the lysogenic phage and another for the lytic phage. While researching the project, we found that antibiotic resistance is as much of an issue in the farming world as it is in hospitals, so we also investigated this potential route for PhagED as part of our human practices.

    Through discussions with experts from both the healthcare and animal industries, we realised that a spray wasn’t the best way to deploy our system.

    In hospital settings, powdered detergents and dissolvable cleaning agents are commonly used instead of sprays. Therefore, we decided to focus on PhagED as a powder rather than a spray. As our computational model demonstrated, the provision of nutrients to the system enhances the ability of the phages to remove resistant bacteria. Nutrient powder could therefore be mixed with the powdered phages to create the most efficient possible PhagED. By encapsulating the powdered phages in different coatings, their rate of dissolving can be controlled - allowing the system to be applied in a single stage while ensuring that the lysogenic phages are the first to contact the resistant bacteria.

    Powdered PhagED would also be applicable in farm environments, where it could be used for cleaning equipment etc., but also potentially as a food additive. For a product like this to be viable, it would have to be cost-effective and easily incorporated into current routines and treatments.

    To see the key points that we learnt from each expert and how they affected our plans for PhagED, click on the photographs below.

  • Dr. Beth Reilly

  • How do I change my password?

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  • Andrew McGregor

  • How does syncing work?

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  • Dr Yusuf Ali Lalloo

  • How do I change my password?

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  • Karine Moore

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