(Prototype team page) |
|||
(22 intermediate revisions by 2 users not shown) | |||
Line 2: | Line 2: | ||
<html> | <html> | ||
− | + | <style> | |
− | < | + | .column li { |
− | + | list-style-type: decimal; | |
− | + | } | |
− | + | </style> | |
− | + | ||
− | + | ||
<div class="column full_size"> | <div class="column full_size"> | ||
− | <h1> | + | <h1 class="subtitle text-center">Model: Homepage</h1> |
− | + | <p>The overall goal of PhagED is to stop infections and deaths caused by antibiotic resistant pathogens. In the strategy that we use, the key step is to re-sensitise antibiotic resistant populations of bacteria using a system of two phages. In order to | |
− | <p> | + | improve our understanding of complex interactions between these populations and at the same time to overcome the limitations imposed by the lack resources, such as finance and time available for the research, we developed an <em>in silico</em> model. |
− | + | </p> | |
− | </ | + | <p>Therefore, the main objective was to develop a mathematical model describing interactions between populations of lysogenic and lytic phages as well as bacteria in one system in continuous and batch processes. This was done by augmenting separate existing |
− | <div class=" | + | models of bacteria-phage interactions described as systems of ordinary (ODEs) and delayed differential equations (DDEs). The model was then used to:</p> |
− | + | <ul> | |
− | <div class=" | + | <li>Run simulations of a continuous process in Python using PyDDE package for solving systems of DDEs and compare the change in populations relative to the previous separate models of lytic phage and bacteria (Levin, Stewart and Chao, 1977), and lysogenic |
− | < | + | phage and bacteria interactions in chemostat (Qiu, 2007).</li> |
− | < | + | <li>Perform a local sensitivity analysis of the model parameters by calculating the elasticity for each parameter in Python to identify the key parameters that are largely responsible for the variation in the model output.</li> |
− | + | </ul> | |
− | </ | + | <p>Our model is divided into four parts that you can see below. At the end of each part you will find the menu, similar to the one below, to help you navigate around. </p> |
− | + | <div class="row model-menu"> | |
− | < | + | <div class="col-md-6 col-lg-6 col-xs-12"> |
− | + | <div class="media wow fadeInUp animated animated" data-wow-duration="500ms" data-wow-delay="300ms" style="visibility: visible; animation-duration: 500ms; animation-delay: 300ms; animation-name: fadeInUp;"> | |
− | </p> | + | <div class="media-left"> |
− | </div> | + | <div class="icon"> |
− | + | <i class="ion-map"></i> | |
− | <div class=" | + | </div> |
− | < | + | </div> |
− | + | <div class="media-body"> | |
− | < | + | <h4 class="media-heading">Background</h4> |
− | + | <p>Review of existing models of bacteria-phage interactions with their assumptions and limitations.</p> | |
− | < | + | </div> |
− | + | </div> | |
− | </ | + | </div> |
− | + | <div class="col-md-6 col-lg-6 col-xs-12"> | |
− | </div> | + | <div class="media wow fadeInDown animated animated" data-wow-duration="500ms" data-wow-delay="600ms" style="visibility: visible; animation-duration: 500ms; animation-delay: 600ms; animation-name: fadeInDown;"> |
− | <div class=" | + | <div class="media-left"> |
− | + | <div class="icon"> | |
− | <div class=" | + | <i class="ion-ios-flask-outline"></i> |
− | < | + | </div> |
− | < | + | </div> |
− | + | <div class="media-body"> | |
− | </ | + | <h4 class="media-heading">Methodology</h4> |
− | < | + | <p>Here we present the methodology that was developed and used for the model.</p> |
− | < | + | </div> |
− | < | + | </div> |
− | < | + | </div> |
− | < | + | <div class="col-md-6 col-lg-6 col-xs-12"> |
− | </ | + | <div class="media wow fadeInDown animated animated" data-wow-duration="500ms" data-wow-delay="900ms" style="visibility: visible; animation-duration: 500ms; animation-delay: 900ms; animation-name: fadeInDown;"> |
− | + | <div class="media-left"> | |
+ | <div class="icon"> | ||
+ | <i class="ion-arrow-graph-up-right"></i> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="media-body"> | ||
+ | <h4 class="media-heading">Results</h4> | ||
+ | <p>Here we present the results of simulations of newly created models, review and analyse together with comparison to other models.</p> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="col-md-6 col-lg-6 col-xs-12"> | ||
+ | <div class="media wow fadeInDown animated animated" data-wow-duration="500ms" data-wow-delay="1200ms" style="visibility: visible; animation-duration: 500ms; animation-delay: 1200ms; animation-name: fadeInDown;"> | ||
+ | <div class="media-left"> | ||
+ | <div class="icon"> | ||
+ | <i class="ion-document"></i> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="media-body"> | ||
+ | <h4 class="media-heading">References</h4> | ||
+ | <p>We gathered almost all up-to-date scientific literature about phage-bacteria interactions.</p> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | </div> | ||
+ | <div class="btn-row"> | ||
+ | <div><a class="btn-result btn-active" style="width:90%;" data-wow-delay=".9s" href="https://2017.igem.org/Team:Edinburgh_OG/Model" style="visibility: visible; animation-delay: 0.9s;">Model Homepage</a></div> | ||
+ | <div style="clear:both;"><a class="btn-result" data-wow-delay=".9s" href="https://2017.igem.org/Team:Edinburgh_OG/Model:Background" style="visibility: visible; animation-delay: 0.9s;">Background</a> | ||
+ | <a class="btn-result" data-wow-delay=".9s" href="https://2017.igem.org/Team:Edinburgh_OG/Model:Methodology" style="visibility: visible; animation-delay: 0.9s;">Methodology</a></div> | ||
+ | <div style="clear:both;" class="btn-row"><a class="btn-result" data-wow-delay=".9s" href="https://2017.igem.org/Team:Edinburgh_OG/Model:Results" style="visibility: visible; animation-delay: 0.9s;">Results</a> | ||
+ | <a class="btn-result" data-wow-delay=".9s" href="https://2017.igem.org/Team:Edinburgh_OG/Model:References" style="visibility: visible; animation-delay: 0.9s;">References</a></div> | ||
+ | </div> | ||
</div> | </div> | ||
</html> | </html> |
Latest revision as of 03:33, 2 November 2017
Model: Homepage
The overall goal of PhagED is to stop infections and deaths caused by antibiotic resistant pathogens. In the strategy that we use, the key step is to re-sensitise antibiotic resistant populations of bacteria using a system of two phages. In order to improve our understanding of complex interactions between these populations and at the same time to overcome the limitations imposed by the lack resources, such as finance and time available for the research, we developed an in silico model.
Therefore, the main objective was to develop a mathematical model describing interactions between populations of lysogenic and lytic phages as well as bacteria in one system in continuous and batch processes. This was done by augmenting separate existing models of bacteria-phage interactions described as systems of ordinary (ODEs) and delayed differential equations (DDEs). The model was then used to:
- Run simulations of a continuous process in Python using PyDDE package for solving systems of DDEs and compare the change in populations relative to the previous separate models of lytic phage and bacteria (Levin, Stewart and Chao, 1977), and lysogenic phage and bacteria interactions in chemostat (Qiu, 2007).
- Perform a local sensitivity analysis of the model parameters by calculating the elasticity for each parameter in Python to identify the key parameters that are largely responsible for the variation in the model output.
Our model is divided into four parts that you can see below. At the end of each part you will find the menu, similar to the one below, to help you navigate around.