TengjieCPU (Talk | contribs) |
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<h4><br>To solve the problems existing in the current treatment of RA, we design and build a brand new immunotherapy. FOXP3+ regulatory T cells, which can suppress and regulate immune reaction, are engineered by inserting a chimeric antigen receptor (CAR) using lentiviral vectors to recognize RA related inflammatory cells. At the same time, we insert another receptor to activate the functional stability pathway of regulatory T cells in the inflammatory environment, thus making it possible for them to be more immunosuppressive and more stable in lesions in hope for a better anti-RA effect. These two redirections of the two different systems on the native regulatory T cell response ensure both the efficacy and efficiency of our novel immunotherapy for RA.</h4> | <h4><br>To solve the problems existing in the current treatment of RA, we design and build a brand new immunotherapy. FOXP3+ regulatory T cells, which can suppress and regulate immune reaction, are engineered by inserting a chimeric antigen receptor (CAR) using lentiviral vectors to recognize RA related inflammatory cells. At the same time, we insert another receptor to activate the functional stability pathway of regulatory T cells in the inflammatory environment, thus making it possible for them to be more immunosuppressive and more stable in lesions in hope for a better anti-RA effect. These two redirections of the two different systems on the native regulatory T cell response ensure both the efficacy and efficiency of our novel immunotherapy for RA.</h4> | ||
<div> | <div> | ||
− | <center><img src="https://static.igem.org/mediawiki/2017/5/56/T--CPU_CHINA--des-figure4.png"width = " | + | <center><img src="https://static.igem.org/mediawiki/2017/5/56/T--CPU_CHINA--des-figure4.png"width = "700"></center> |
<center>Figure 1</center> | <center>Figure 1</center> | ||
</div> | </div> | ||
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<h4><br>SynNotch is a system that is capable of specifically activating the expression of the USP7 gene in an inflammatory environment, thereby maintaining the activity of Treg cells by stabilizing the FOXP3 proteins.</h4> | <h4><br>SynNotch is a system that is capable of specifically activating the expression of the USP7 gene in an inflammatory environment, thereby maintaining the activity of Treg cells by stabilizing the FOXP3 proteins.</h4> | ||
<div> | <div> | ||
− | <center><img src="https://static.igem.org/mediawiki/2017/5/53/T--CPU_CHINA--eng-figure3_7.png" heigth = " | + | <center><img src="https://static.igem.org/mediawiki/2017/5/53/T--CPU_CHINA--eng-figure3_7.png" heigth = "300"></center> |
<center>Figure 2</center> | <center>Figure 2</center> | ||
</div> | </div> |
Revision as of 13:51, 30 October 2017