Team:Tongji China
Model
Awards
HP
home
project
team
lab
Description
There are many people who dead of disease that are spread by mosquitoes such as malaria, dengue fever and Zika. According to WHO’s report, there are 429,000 deaths from malaria occurred in 2015.
We find an article reported that pharmacological manipulation of dopamine could alter fruits fly’s sexual behavior. Mosquito and fruit fly all belong to Diptera, the system that was used in fly can also be used in mosquitos. Finally we used a specificity promoter pleP that is only activated in dopaminergic neuron and Gal80ts protein that is only activated in low temperature condition, and UAS-GAL4 system to alter fruits fly’s sexual behavior to control the population of fly or mosquitoes.
We can continue to optimize our system. For example, we can put these parts in one chromosome. We can also use different mutant that is applicable for different temperature zone. And this way can combine with Oxitec and Wolbachia to improve the effect of reduce population.
We find an article reported that pharmacological manipulation of dopamine could alter fruits fly’s sexual behavior. Mosquito and fruit fly all belong to Diptera, the system that was used in fly can also be used in mosquitos. Finally we used a specificity promoter pleP that is only activated in dopaminergic neuron and Gal80ts protein that is only activated in low temperature condition, and UAS-GAL4 system to alter fruits fly’s sexual behavior to control the population of fly or mosquitoes.
We can continue to optimize our system. For example, we can put these parts in one chromosome. We can also use different mutant that is applicable for different temperature zone. And this way can combine with Oxitec and Wolbachia to improve the effect of reduce population.
Address:1239 Siping Road, Shanghai, P.R China
Tel:+86-21-65982200
Contact us:
email:tju_igem_2017@163.com
Twitter:Twitter@iGEM_Tongji_CN
