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| − | <p>Each year Enterotoxigenic Escherichia coli (ETEC), a form of pathogenic <I>E. coli</I> known for causing traveler’s stomach, affects millions of travelers. ETEC produces two toxins, a heat labile and a heat stable version. The basis of the project is to complete three different steps: sense ETEC, respond to its presence, and package the sense/response module in a cellulose matrix.</p>
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| − | <p>The goal of the sensing step is to engineer a non-pathogenic <I>E. coli</I> to detect the pathogenic <I>E.coli</I> communication signals. The response section involves engineering the same <I>E. coli</I> to glow green upon the detection of harmful bacteria. In order to package the sense and respond <I>E. coli</I>, cellulose binding domains will be engineered to be expressed on the Csg A portions of curli surface proteins on <I>E. coli</I>.</p>
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| − | <p>We chose this project after brainstorming many problems that the United States Air Force airmen face on a daily basis. Traveling far and wide for months at a time, those deployed become susceptible to many pathogens in the water supply, especially harmful strains of <I>E. coli</I>. As ETEC is the most common cause of traveler's stomach, we can help to detect and using this modular system, potentially eradicate the pathogens from the water and the body. </p>
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Revision as of 23:18, 31 August 2017
