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| − | <h1>Description</h1> | + | <h1>Project Description</h1> |
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| − | <p>Tell us about your project, describe what moves you and why this is something important for your team.</p>
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| − | <h5>What should this page contain?</h5>
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| − | <ul>
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| − | <li> A clear and concise description of your project.</li>
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| − | <li>A detailed explanation of why your team chose to work on this particular project.</li>
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| − | <li>References and sources to document your research.</li>
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| − | <li>Use illustrations and other visual resources to explain your project.</li>
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| − | </ul>
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| − | <div class="column full_size" > | + | <div class="text"> |
| | + | <h2>Description</h2> |
| | + | <p>Each year Enterotoxigenic Escherichia coli (ETEC), a form of pathogenic <I>E. coli</I> known for causing traveler’s stomach, affects millions of travelers. ETEC produces two toxins, a heat labile and a heat stable version. The basis of the project is to complete three different steps: sense ETEC, respond to its presence, and package the sense/response module in a cellulose matrix.</p> |
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| − | <h5>Advice on writing your Project Description</h5> | + | <p>The goal of the sensing step is to engineer a non-pathogenic <I>E. coli</I> to detect the pathogenic <I>E. coli</I> communication signals. The response section involves engineering the same <I>E. coli</I> to glow green upon the detection of harmful bacteria. In order to package the sense and respond <I>E. coli</I>, cellulose binding domains will be engineered to be expressed on the CsgA portions of curli specific proteins on <I>E. coli</I>.</p> |
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| − | <p> | + | <p>We chose this project after brainstorming many problems that United States Air Force personnel face on a daily basis. Traveling for months at a time, those deployed become susceptible to many pathogens in the water supply, especially harmful strains of <I>E. coli</I>. ETEC is the most common cause of traveler's stomach. We can help detect ETEC by using this modular system, potentially eradicating the pathogens from the water and the body.</p> |
| − | We encourage you to put up a lot of information and content on your wiki, but we also encourage you to include summaries as much as possible. If you think of the sections in your project description as the sections in a publication, you should try to be consist, accurate and unambiguous in your achievements. | + | |
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| − | Judges like to read your wiki and know exactly what you have achieved. This is how you should think about these sections; from the point of view of the judge evaluating you at the end of the year.
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| − | </p>
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| − | </div> | + | <img src="https://static.igem.org/mediawiki/2017/thumb/e/ef/TDPie.png/800px-TDPie.png" style="height: auto; width: 60%; margin-right: 20%; margin-left: 20%;"> |
| − | | + | <p class="caption" style="width=70%; margin-left: 15%; margin-right: 15%;" >Figure 1 Graph showing the percent of personnel who experience diarrhea during deployment and number of episodes experienced</p> |
| − | | + | <img src="https://static.igem.org/mediawiki/2017/thumb/5/58/TDImpact2.png/800px-TDImpact2.png" style="height: auto; width: 60%; margin-right: 20%; margin-left: 20%;"> |
| − | <div class="column half_size" > | + | <p class="caption" style="width=70%; margin-left: 15%; margin-right: 15%;" >Figure 2 This chart shows the results of a survey of deployed personnel who experienced diarrhea during deployment concerning its impact on performance</p> |
| − | | + | <img src="https://static.igem.org/mediawiki/2017/3/30/TDCause2.png" style="height: auto; width: 60%; margin-right: 20%; margin-left: 20%;"> |
| − | <h5>References</h5> | + | <p class="caption" style="width=70%; margin-left: 15%; margin-right: 15%;" >Figure 3 Chart showing the causes of diarrheal illness; the outer ring displays causes for deployed military and the inner for civilian travelers</p> |
| − | <p>iGEM teams are encouraged to record references you use during the course of your research. They should be posted somewhere on your wiki so that judges and other visitors can see how you thought about your project and what works inspired you.</p> | + | |
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| − | <h5>Inspiration</h5>
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| − | <p>See how other teams have described and presented their projects: </p>
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| − | <ul>
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| − | <li><a href="https://2016.igem.org/Team:Imperial_College/Description">2016 Imperial College</a></li>
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| − | <li><a href="https://2016.igem.org/Team:Wageningen_UR/Description">2016 Wageningen UR</a></li>
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| − | <li><a href="https://2014.igem.org/Team:UC_Davis/Project_Overview"> 2014 UC Davis</a></li>
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| − | <li><a href="https://2014.igem.org/Team:SYSU-Software/Overview">2014 SYSU Software</a></li>
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| − | </ul>
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