Difference between revisions of "Team:US AFRL CarrollHS/HP/Gold Integrated"

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<h3>★  ALERT! </h3>
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<p>This page is used by the judges to evaluate your team for the <a href="https://2017.igem.org/Judging/Medals">medal criterion</a> or <a href="https://2017.igem.org/Judging/Awards"> award listed above</a>. </p>
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<p> Delete this box in order to be evaluated for this medal criterion and/or award. See more information at <a href="https://2017.igem.org/Judging/Pages_for_Awards"> Instructions for Pages for awards</a>.</p>
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<h1>Gold Medal and Integrated Human Practices</h1>
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    <h1>Integrated and Gold Human Practices</h1>
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<h2>Integrated Human Practices </h2>
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<p>For the Integrated Human Practices, our team searched through the iGEM registry for a possible kill switch for our microbe. A kill switch would be useful in making people feel more comfortable ingesting the capsule or placing it in potential drinking water. A kill switch would allow the bacteria to be shut down or limited to make sure the population does not grow uncontrollably. We also looked for parts that might improve our project to prevent people from becoming ill due to other harmful bacteria and molecules.Two parts were found that we could use in continuation projects in the next few years. These parts are a population capping device and a dCBD improvement that can bind to metals.  </p>
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<p>This page will contain information for your Gold medal Human Practices work, which you can also use to nominate your team for the Best Integrated Human Practices page. To make things easier, we have combined the Gold medal page with the Best Integrated Human Practices page since we expect the work to overlap considerably. </p>
 
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<p>iGEM teams are unique and leading the field because they "go beyond the lab" to imagine their projects in a social/environmental context, to better understand issues that might influence the design and use of their technologies.</p>
 
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<p>Teams work with students and advisors from the humanities and social sciences to explore topics concerning ethical, legal, social, economic, safety or security issues related to their work. Consideration of these Human Practices is crucial for building safe and sustainable projects that serve the public interest. </p>
 
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<p>For more information, please see the <a href="https://2017.igem.org/Competition/Human_Practices">Human Practices page</a>.</p>
 
 
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<h3>Gold Medal Criterion #1</h3>
 
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<p>Expand on your silver medal activity by demonstrating how you have integrated the investigated issues into the design and/or execution of your project.</p>
 
  
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<h2>xylR+PxylA+RBS+ydcE+Ptms+RBS+ydcD: Cell Growth Inhibition Device</h2>
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<h3>iGEM Registry Part: BBa_k733012</h3>
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<p>This part is a growth inhibition device that makes a cell release BMP2 which slows or stops the growth of bacteria. In the future, this part can be modified to keep the cell population of our <i>E. coli</i> controlled in the colon of humans or in water. It would prevent the cells from growing and overtaking the cells already living in the ecosystem. This part is already modified for cells in the colon and could be a great addition to our <i>E. coli</i>.</p>
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<h3>Best Integrated Human Practices Special Prize</h3>
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To compete for the <a href="https://2017.igem.org/Judging/Awards">Best Integrated Human Practices prize</a>, please describe your work on this page and also fill out the description on the <a href="https://2017.igem.org/Judging/Judging_Form">judging form</a>.
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<h2>Phytochelatin (PC) EC20 fused to linker-dCBD with LacI</h2>
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<h3>iGEM Registry Part: Part:BBa_K1321110</h3>
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You must also delete the message box on the top of this page to be eligible for this prize.
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<p>This part uses the double cellulose binding domain (dCBD) that is part of the packaging for our <i>E. coli</i>. This dCBD linker creates a site within the dCBD that binds the cellulose to a metal. This can be useful for our project if we combine it with our dCDB, because it could recognize the presence of a metal with the potential to harm humans when the <i>E. coli</i> cells are in the digestive system or water sample. With this additional part, the cellulose would bind to the metal and trap it so that it can then be tested for different metals.</p>
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<h5>Inspiration</h5>
 
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<p>Here are a few examples of excellent Integrated Human Practices work:</p>
 
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<li><a href="https://2016.igem.org/Team:INSA-Lyon/Integrated_Practices">2016 INSA Lyon</a></li>
 
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<li><a href="https://2016.igem.org/Team:UofC_Calgary/Integrated_Practices">2016 UofC Calgary</a></li>
 
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<li><a href="https://2015.igem.org/Team:Bielefeld-CeBiTec/Practices">2015 Bielefeld</a></li>
 
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<li><a href="https://2015.igem.org/Team:Edinburgh/Practices">2015 Edinburgh</a></li>
 
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Latest revision as of 00:50, 2 November 2017


Integrated and Gold Human Practices

Integrated Human Practices

For the Integrated Human Practices, our team searched through the iGEM registry for a possible kill switch for our microbe. A kill switch would be useful in making people feel more comfortable ingesting the capsule or placing it in potential drinking water. A kill switch would allow the bacteria to be shut down or limited to make sure the population does not grow uncontrollably. We also looked for parts that might improve our project to prevent people from becoming ill due to other harmful bacteria and molecules.Two parts were found that we could use in continuation projects in the next few years. These parts are a population capping device and a dCBD improvement that can bind to metals.


xylR+PxylA+RBS+ydcE+Ptms+RBS+ydcD: Cell Growth Inhibition Device

iGEM Registry Part: BBa_k733012

This part is a growth inhibition device that makes a cell release BMP2 which slows or stops the growth of bacteria. In the future, this part can be modified to keep the cell population of our E. coli controlled in the colon of humans or in water. It would prevent the cells from growing and overtaking the cells already living in the ecosystem. This part is already modified for cells in the colon and could be a great addition to our E. coli.

Phytochelatin (PC) EC20 fused to linker-dCBD with LacI

iGEM Registry Part: Part:BBa_K1321110

This part uses the double cellulose binding domain (dCBD) that is part of the packaging for our E. coli. This dCBD linker creates a site within the dCBD that binds the cellulose to a metal. This can be useful for our project if we combine it with our dCDB, because it could recognize the presence of a metal with the potential to harm humans when the E. coli cells are in the digestive system or water sample. With this additional part, the cellulose would bind to the metal and trap it so that it can then be tested for different metals.