SongChenyu (Talk | contribs) |
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margin-bottom: 40px; | margin-bottom: 40px; | ||
z-index: 900; | z-index: 900; | ||
+ | } | ||
+ | |||
+ | a { | ||
+ | text-decoration: none; | ||
+ | color: rgba(20,20,20,1); | ||
+ | } | ||
+ | /* unvisited link */ | ||
+ | a:link { | ||
+ | color: green; | ||
+ | } | ||
+ | |||
+ | /* visited link */ | ||
+ | a:visited { | ||
+ | color: DarkGreen; | ||
+ | } | ||
+ | |||
+ | /* mouse over link */ | ||
+ | a:hover { | ||
+ | color: red; | ||
+ | } | ||
+ | |||
+ | /* selected link */ | ||
+ | a:active { | ||
+ | color: blue; | ||
} | } | ||
Line 90: | Line 114: | ||
.logolayout{ | .logolayout{ | ||
− | + | width: 22% !important; | |
− | + | margin: 1.5% !important; | |
+ | } | ||
+ | |||
+ | @font-face { | ||
+ | font-family: NewCustomFont; | ||
+ | src: url(https://static.igem.org/mediawiki/2017/8/87/2017tongji_fonts_homepage.ttf) format('truetype'); | ||
+ | } | ||
+ | |||
+ | /*DROPDOWN*/ | ||
+ | |||
+ | .dropdown { | ||
+ | position: relative; | ||
+ | display: inline-block; | ||
+ | vertical-align: bottom; | ||
+ | width: 100px; | ||
+ | height: 150px; | ||
+ | top: 50px; | ||
+ | padding-left: 10px; | ||
+ | padding-right: 10px; | ||
+ | } | ||
+ | .dropdown a { | ||
+ | /*color: black;*/ | ||
+ | /*padding: 16px;*/ | ||
+ | text-align: center; | ||
+ | text-decoration: none; | ||
+ | /*display: block;*/ | ||
+ | font-family: NewCustomFont; | ||
+ | } | ||
+ | /*.dropdown:hover { | ||
+ | background-color: rgba(255,255,255,0.66); | ||
+ | }*/ | ||
+ | /*.dropdown a { | ||
+ | vertical-align: bottom; | ||
+ | z-index: 999; | ||
+ | }*/ | ||
+ | /*.dropdown-back { | ||
+ | position: absolute; | ||
+ | bottom: 0px; | ||
+ | left: 0px; | ||
+ | background-color: rgba(255,255,255,0); | ||
+ | width: 100%; | ||
+ | height: 100px; | ||
+ | }*/ | ||
+ | /*.dropdown:hover .dropdown-back { | ||
+ | background-color: rgba(255,255,255,0.66); | ||
+ | }*/ | ||
+ | |||
+ | .dropdown-content { | ||
+ | display: none; | ||
+ | position: absolute; | ||
+ | background-color: rgba(255,255,255,0.5); | ||
+ | width: 140px; | ||
+ | /*min-width: 160px;*/ | ||
+ | /*box-shadow: 0px 8px 16px 0px rgba(0,0,0,0.2);*/ | ||
+ | z-index: 1; | ||
+ | } | ||
+ | .dropdown-content a { | ||
+ | /*color: black;*/ | ||
+ | padding-top: 8px; | ||
+ | padding-bottom: 8px; | ||
+ | /*padding-left: 8px;*/ | ||
+ | /*padding-right: 8px;*/ | ||
+ | text-decoration: none; | ||
+ | display: block; | ||
+ | /*font-size: 120%;*/ | ||
+ | font-family: NewCustomFont; | ||
+ | } | ||
+ | .dropdown:hover .dropdown-content { | ||
+ | display: block; | ||
+ | } | ||
+ | .dropdown-content a:hover {background-color: rgba(255,255,255,0.8)} | ||
+ | |||
+ | .dropdown-title { | ||
+ | width: 140px; | ||
+ | } | ||
+ | .dropdown-title a { | ||
+ | padding-top: 8px; | ||
+ | padding-bottom: 8px; | ||
+ | padding-left: 16px; | ||
+ | padding-right: 16px; | ||
+ | text-decoration: none; | ||
+ | display: block; | ||
+ | font-size: 130%; | ||
+ | font-family: NewCustomFont; | ||
+ | } | ||
+ | .dropdown:hover .dropdown-title { | ||
+ | background-color: rgba(255,255,255,0.5); | ||
+ | } | ||
+ | .dropdown-title a:hover {background-color: rgba(255,255,255,0.8)} | ||
+ | |||
+ | .dropdown-image { | ||
+ | padding-left: 20px; | ||
+ | padding-right: 20px; | ||
+ | } | ||
+ | |||
+ | .desktopview { | ||
+ | position: relative; | ||
+ | height: 800px; | ||
+ | width: auto; | ||
+ | background-color: #f3f3f3; | ||
+ | background: url('https://static.igem.org/mediawiki/2017/9/9f/2017_tongji_wiki_image_homepage_backgroud2.png') center no-repeat; | ||
+ | background-size: cover; | ||
+ | } | ||
+ | |||
+ | .mobileview-header { | ||
+ | } | ||
+ | |||
+ | .mobileview-drawer { | ||
+ | } | ||
+ | |||
+ | .mobileview-title { | ||
+ | padding-top: 100px | ||
+ | } | ||
+ | |||
+ | .disappear-on-mobile { | ||
} | } | ||
Line 100: | Line 238: | ||
} | } | ||
} | } | ||
+ | |||
+ | @media only screen and (min-device-width: 900px) { | ||
+ | .mobileview-header { | ||
+ | position: absolute !important; | ||
+ | top: -1000px !important; | ||
+ | } | ||
+ | .mobileview-drawer { | ||
+ | position: absolute !important; | ||
+ | top: -1000px !important; | ||
+ | } | ||
+ | .mobileview-title { | ||
+ | position: absolute !important; | ||
+ | top: -1000px !important; | ||
+ | } | ||
+ | } | ||
@media only screen and (max-device-width: 900px) { | @media only screen and (max-device-width: 900px) { | ||
Line 112: | Line 265: | ||
margin: 3% !important; | margin: 3% !important; | ||
} | } | ||
+ | .desktopview { | ||
+ | position: absolute !important; | ||
+ | top: -1000px !important; | ||
+ | display: none !important; | ||
+ | background: none; | ||
+ | } | ||
+ | /*.mobileview-header { | ||
+ | display: flex !important; | ||
+ | } | ||
+ | .mobileview-drawer { | ||
+ | display: block !important; | ||
+ | }*/ | ||
} | } | ||
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width: 45% !important; | width: 45% !important; | ||
margin: 2% !important; | margin: 2% !important; | ||
+ | } | ||
+ | .disappear-on-mobile { | ||
+ | display:none !important; | ||
} | } | ||
} | } | ||
Line 137: | Line 305: | ||
document.getElementById('content').style.width='100%'; | document.getElementById('content').style.width='100%'; | ||
} | } | ||
+ | window.setTimeout(closeMenuDiv,0); | ||
+ | window.setTimeout(closeMenuDiv,10); | ||
+ | window.setTimeout(closeMenuDiv,20); | ||
window.setTimeout(closeMenuDiv,50); | window.setTimeout(closeMenuDiv,50); | ||
window.setTimeout(closeMenuDiv,100); | window.setTimeout(closeMenuDiv,100); | ||
+ | window.setTimeout(closeMenuDiv,200); | ||
window.setTimeout(closeMenuDiv,500); | window.setTimeout(closeMenuDiv,500); | ||
window.setTimeout(closeMenuDiv,1000); | window.setTimeout(closeMenuDiv,1000); | ||
+ | window.setTimeout(closeMenuDiv,2000); | ||
window.setTimeout(closeMenuDiv,5000); | window.setTimeout(closeMenuDiv,5000); | ||
window.setTimeout(closeMenuDiv,10000); | window.setTimeout(closeMenuDiv,10000); | ||
+ | window.setTimeout(closeMenuDiv,20000); | ||
function playIntroVideo(){ | function playIntroVideo(){ | ||
Line 150: | Line 324: | ||
</script> | </script> | ||
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− | |||
</head> | </head> | ||
− | <body | + | <body> |
+ | <div class="mdl-layout mdl-js-layout mdl-layout--fixed-header" class="main view" style="background:#f9f9f9"> | ||
+ | <a name="top"></a> | ||
− | + | <!-- MOBILE VIEW --> | |
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
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− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
− | + | ||
<!-- Header --> | <!-- Header --> | ||
− | + | <div class="android-header mdl-layout__header mdl-layout__header--waterfall mobileview-header"> | |
+ | <div class="mdl-layout__header-row"> | ||
+ | <span class="android-title mdl-layout-title"> | ||
+ | <div class="logo-font">Tongji iGEM</div> | ||
+ | </span> | ||
+ | <!-- Add spacer, to align navigation to the right in desktop --> | ||
+ | <div class="android-header-spacer mdl-layout-spacer"></div> | ||
+ | <!-- Navigation --> | ||
+ | <div class="android-navigation-container"> | ||
+ | <nav class="android-navigation mdl-navigation"> | ||
+ | <!-- Links in the top right --> | ||
+ | <a class="mdl-navigation__link mdl-typography--text-uppercase" href="https://2017.igem.org/Team:Tongji_China">Home</a> | ||
+ | <a class="mdl-navigation__link mdl-typography--text-uppercase" href="https://2017.igem.org/Team:Tongji_China/Description">Project</a> | ||
+ | <a class="mdl-navigation__link mdl-typography--text-uppercase" href="https://2017.igem.org/Team:Tongji_China/Team">Team</a> | ||
+ | <a class="mdl-navigation__link mdl-typography--text-uppercase" href="https://2017.igem.org/Team:Tongji_China/Results">Results</a> | ||
+ | </nav> | ||
+ | </div> | ||
+ | <span class="android-mobile-title mdl-layout-title"> | ||
+ | <div class="logo-font">Tongji iGEM</div> | ||
+ | </span> | ||
+ | </div> | ||
+ | </div> | ||
<!-- Drawer --> | <!-- Drawer --> | ||
− | <div class="android-drawer mdl-layout__drawer"> | + | <div class="android-drawer mdl-layout__drawer mobileview-drawer"> |
<nav class="mdl-navigation"> | <nav class="mdl-navigation"> | ||
<!-- <span class="mdl-navigation__link" href="">Title</span> --> | <!-- <span class="mdl-navigation__link" href="">Title</span> --> | ||
Line 291: | Line 401: | ||
</nav> | </nav> | ||
</div> | </div> | ||
− | |||
<!-- HERE STARTS THE PAGE --> | <!-- HERE STARTS THE PAGE --> | ||
<div class="android-content mdl-layout__content"> | <div class="android-content mdl-layout__content"> | ||
<a name="top"></a> | <a name="top"></a> | ||
+ | |||
<!-- Title and Subtitle --> | <!-- Title and Subtitle --> | ||
− | <div class="mdl-typography--text-center" style="height: | + | <div class="mdl-typography--text-center mobileview-title" style="height:700px; background:url('https://static.igem.org/mediawiki/2017/9/9f/2017_tongji_wiki_image_homepage_backgroud2.png') center no-repeat; background-size:cover;"> |
− | + | <div class="logo-font android-slogan" style="color:#388E3C;">Ignis Fly</div> | |
+ | <div class="logo-font android-sub-slogan" style="color:#757575;"> | ||
+ | Welcome to our wiki!<br> | ||
+ | <!-- <i class="material-icons">expand_more</i> --> | ||
+ | </div> | ||
</div> | </div> | ||
− | + | ||
− | + | <!-- DESKTOP VIEW --> | |
+ | <div class="desktopview" style=""> | ||
+ | |||
+ | <!-- Ignis Fly Title --> | ||
+ | <div style="position:relative; margin:auto; left:0; right:0; bottom:0; top:0; width:100%; height:100%; text-align:center; vertical-align:middle;"> | ||
+ | <img style="margin-top:250px; width:600px; opacity:0.8" src="https://static.igem.org/mediawiki/2017/3/3b/2017_tongji_wiki_homepage_title-NEW.png" alt="Ignis Fly"> | ||
+ | </div> | ||
+ | |||
+ | <!-- Tongji iGEM Logo --> | ||
+ | <!-- <div style="position:absolute; left:0; top:0; width:150px; height:auto;"> | ||
+ | <img width="100%" style="" src="https://static.igem.org/mediawiki/2017/8/82/2017_tongji_wiki_image_homepage_logo_of_tongji.png" alt="Ignis Fly"> | ||
+ | </div> --> | ||
+ | |||
+ | <!-- Icons --> | ||
+ | <div style="position:absolute; top:0px; left:0px; width:100%; height:170px; text-align:center"> | ||
+ | |||
+ | <div style="position:absolute; bottom:0px; left:0px; width:100%; height:85px; background:rgba(255,255,255,0.5);"> | ||
+ | </div> | ||
+ | |||
+ | <div style="position:absolute; bottom:0px; left:0px; width:100%; height:200px; text-align:center; margin-right: 40px"> | ||
+ | |||
+ | <div class="dropdown"> | ||
+ | <div class="dropdown-back"></div> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Model"> | ||
+ | <img class="dropdown-image" src="https://static.igem.org/mediawiki/2017/3/30/2017_tongji_wiki_homepage_image_MODEL2.png" alt="Model" width="100%" height="100%"> | ||
+ | <!-- <div class="dropdown-title">Model</div> --> | ||
+ | </a> | ||
+ | <div class="dropdown-title"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Model" style="font-family: NewCustomFont;"> | ||
+ | Model | ||
+ | </a> | ||
+ | </div> | ||
+ | <!-- <div class="dropdown-content"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Team" style="font-family: NewCustomFont;"> | ||
+ | Team | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Attributions" style="font-family: NewCustomFont;"> | ||
+ | Attributions | ||
+ | </a> | ||
+ | </div> --> | ||
+ | </div> | ||
+ | |||
+ | <div class="dropdown"> | ||
+ | <div class="dropdown-back"></div> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Judging_Form"> | ||
+ | <img class="dropdown-image" src="https://static.igem.org/mediawiki/2017/5/5c/2017_tongji_wiki_homepage_image_awards.png" alt="Awards" width="100%" height="100%"> | ||
+ | <!-- <div class="dropdown-title">Awards</div> --> | ||
+ | </a> | ||
+ | <div class="dropdown-title"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Judging_Form" style="font-family: NewCustomFont;"> | ||
+ | Awards | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="dropdown-content"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Judging_Form" style="font-family: NewCustomFont;"> | ||
+ | Judging Form | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Model" style="font-family: NewCustomFont;"> | ||
+ | Model | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <div class="dropdown"> | ||
+ | <div class="dropdown-back"></div> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Human_Practices"> | ||
+ | <img class="dropdown-image" src="https://static.igem.org/mediawiki/2017/d/d1/2017_tongji_wiki_homepage_image_HP2.png" alt="Human Practices" width="100%" height="100%" style=""> | ||
+ | <!-- <div class="dropdown-title">HP</div> --> | ||
+ | </a> | ||
+ | <div class="dropdown-title"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Human_Practices" style="font-family: NewCustomFont;"> | ||
+ | HP | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="dropdown-content"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/HP/Silver" style="font-family: NewCustomFont;"> | ||
+ | HP Silver | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/HP/Gold_Integrated" style="font-family: NewCustomFont;"> | ||
+ | HP Gold | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Engagement" style="font-family: NewCustomFont;"> | ||
+ | Engagement | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <div class="dropdown"> | ||
+ | <!-- <div class="dropdown-back"></div> --> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China"> | ||
+ | <img class="dropdown-image" src="https://static.igem.org/mediawiki/2017/a/a6/2017_tongji_wiki_homepage_image_home2.png" alt="HOME" width="100%" height="100%" style=""> | ||
+ | </a> | ||
+ | <!-- <div class="dropdown-content"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Team" style="font-family: NewCustomFont;"> | ||
+ | Team | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Attributions" style="font-family: NewCustomFont;"> | ||
+ | Attributions | ||
+ | </a> | ||
+ | </div> --> | ||
+ | </div> | ||
+ | |||
+ | <div class="dropdown"> | ||
+ | <div class="dropdown-back"></div> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Description"> | ||
+ | <img class="dropdown-image" src="https://static.igem.org/mediawiki/2017/9/92/2017_tongji_wiki_homepage_image_PROJECT2.png" alt="Project" width="100%" height="100%" style=""> | ||
+ | <!-- <div class="dropdown-title">Project</div> --> | ||
+ | </a> | ||
+ | <div class="dropdown-title"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Description" style="font-family: NewCustomFont;"> | ||
+ | Project | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="dropdown-content"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Description" style="font-family: NewCustomFont;"> | ||
+ | Description | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Design" style="font-family: NewCustomFont;"> | ||
+ | Design | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Results" style="font-family: NewCustomFont;"> | ||
+ | Results | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <div class="dropdown"> | ||
+ | <div class="dropdown-back"></div> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Team"> | ||
+ | <img class="dropdown-image" src="https://static.igem.org/mediawiki/2017/5/57/2017_tongji_wiki_homepage_image_TEAM2.png" alt="Team" width="100%" height="100%" style=""> | ||
+ | <!-- <div class="dropdown-title">Team</div> --> | ||
+ | </a> | ||
+ | <div class="dropdown-title"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Team" style="font-family: NewCustomFont;"> | ||
+ | Team | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="dropdown-content"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Team" style="font-family: NewCustomFont;"> | ||
+ | Members | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Collaborations" style="font-family: NewCustomFont;"> | ||
+ | Collaborations | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Attributions" style="font-family: NewCustomFont;"> | ||
+ | Attributions | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | <div class="dropdown" style="margin-right: 40px"> | ||
+ | <div class="dropdown-back"></div> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Experiments"> | ||
+ | <img class="dropdown-image" src="https://static.igem.org/mediawiki/2017/3/35/2017_tongji_wiki_homepage_image_LAB2.png" alt="Lab" width="100%" height="100%" style=""> | ||
+ | <!-- <div class="dropdown-title">Lab</div> --> | ||
+ | </a> | ||
+ | <div class="dropdown-title"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Experiments" style="font-family: NewCustomFont;"> | ||
+ | Lab | ||
+ | </a> | ||
+ | </div> | ||
+ | <div class="dropdown-content"> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Experiments" style="font-family: NewCustomFont;"> | ||
+ | Tests | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/Parts" style="font-family: NewCustomFont;"> | ||
+ | Parts | ||
+ | </a> | ||
+ | <a href="https://2017.igem.org/Team:Tongji_China/InterLab" style="font-family: NewCustomFont;"> | ||
+ | InterLab | ||
+ | </a> | ||
+ | </div> | ||
+ | </div> | ||
+ | |||
+ | </div> | ||
+ | </div> | ||
</div> | </div> | ||
+ | |||
<!-- Video --> | <!-- Video --> | ||
<div class="demo-card-wide mdl-card mdl-shadow--2dp"> | <div class="demo-card-wide mdl-card mdl-shadow--2dp"> | ||
− | |||
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<video width="100%" poster="https://static.igem.org/mediawiki/2017/a/aa/2017tongji_images_home_introduction_poster.jpg" id="IntroVideo" controls> | <video width="100%" poster="https://static.igem.org/mediawiki/2017/a/aa/2017tongji_images_home_introduction_poster.jpg" id="IntroVideo" controls> | ||
<source src="https://static.igem.org/mediawiki/2017/5/52/2017tongji_video_home_introduction.mp4" type="video/mp4"> | <source src="https://static.igem.org/mediawiki/2017/5/52/2017tongji_video_home_introduction.mp4" type="video/mp4"> | ||
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<button id="playbutton" style="position:absolute; top:0; left:0; opacity:0; width:100%; height:100%" onclick="playIntroVideo()" type="button"></button> | <button id="playbutton" style="position:absolute; top:0; left:0; opacity:0; width:100%; height:100%" onclick="playIntroVideo()" type="button"></button> | ||
</div> | </div> | ||
− | |||
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<!-- Description --> | <!-- Description --> | ||
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− | There are many people who | + | There are many people who die of diseases that are spread by mosquitoes such as malaria, dengue fever and Zika. According to a WHO’s report, there are 429,000 deaths from malaria occurred in 2015. With our project we hope to help them.<br><br> |
− | We | + | We had the idea for our project after we found an article reporting that pharmacological manipulation of dopamine levels could alter the sexual behaviour of fruits flies. Since mosquitoes and fruit flies both belong to Diptera, the system that was used in flies could also be used in mosquitos. We realised that this could be a way to control the mosquito population, giving use greater control over disease carrying mosquitos without wiping them out entirely. |
+ | For this reason we used the specificity promoter pleP that is only activated in dopaminergic neuron and the Gal80ts protein that is only activated in low temperature condition, and the UAS-GAL4 system to alter the sexual behaviour of fruits flies and control their population.<br><br> | ||
− | We can continue to | + | We are proud to say that our system has given promising results in our experiments and model. This is not the end though, we can continue to optimise our system. For example, we could put the constructs in a single chromosome. We could also extend our system to make it work at different temperatures (and thus environments). This way we will join Oxitec Mosquito and Wolbachia in the fight against disease carrying mosquitoes! |
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− | + | Contact us:<br> | |
− | + | Tel: +86-21-65982200<br> | |
− | + | Email: <a style="padding:0" href="mailto:tju_igem_2017@163.com?Subject=iGEM" target="_top">tju_igem_2017@163.com</a><br> | |
− | <a class="mdl-typography--font-regular mdl-typography--text-uppercase android-alt-link" href="https://2017.igem.org/Team:Tongji_China"> | + | Twitter: <a style="padding:0" href="https://twitter.com/iGEM_Tongji_CN">@iGEM_Tongji_CN</a> |
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Latest revision as of 02:54, 2 November 2017
Tongji iGEM
Tongji iGEM
Ignis Fly
Welcome to our wiki!
The Project
There are many people who die of diseases that are spread by mosquitoes such as malaria, dengue fever and Zika. According to a WHO’s report, there are 429,000 deaths from malaria occurred in 2015. With our project we hope to help them.
We had the idea for our project after we found an article reporting that pharmacological manipulation of dopamine levels could alter the sexual behaviour of fruits flies. Since mosquitoes and fruit flies both belong to Diptera, the system that was used in flies could also be used in mosquitos. We realised that this could be a way to control the mosquito population, giving use greater control over disease carrying mosquitos without wiping them out entirely. For this reason we used the specificity promoter pleP that is only activated in dopaminergic neuron and the Gal80ts protein that is only activated in low temperature condition, and the UAS-GAL4 system to alter the sexual behaviour of fruits flies and control their population.
We are proud to say that our system has given promising results in our experiments and model. This is not the end though, we can continue to optimise our system. For example, we could put the constructs in a single chromosome. We could also extend our system to make it work at different temperatures (and thus environments). This way we will join Oxitec Mosquito and Wolbachia in the fight against disease carrying mosquitoes!
We had the idea for our project after we found an article reporting that pharmacological manipulation of dopamine levels could alter the sexual behaviour of fruits flies. Since mosquitoes and fruit flies both belong to Diptera, the system that was used in flies could also be used in mosquitos. We realised that this could be a way to control the mosquito population, giving use greater control over disease carrying mosquitos without wiping them out entirely. For this reason we used the specificity promoter pleP that is only activated in dopaminergic neuron and the Gal80ts protein that is only activated in low temperature condition, and the UAS-GAL4 system to alter the sexual behaviour of fruits flies and control their population.
We are proud to say that our system has given promising results in our experiments and model. This is not the end though, we can continue to optimise our system. For example, we could put the constructs in a single chromosome. We could also extend our system to make it work at different temperatures (and thus environments). This way we will join Oxitec Mosquito and Wolbachia in the fight against disease carrying mosquitoes!
Ignis Fly
Tongji_China iGEM 2017 Team
Projectchevron_right